Dapoxetine

Clinical Uses

• Premature ejaculation (primary or lifelong)
• Secondary PE due to anxiety or acquired sensitivity
• Combination therapy with PDE5 inhibitors for men with ED + PE

Although off-label studies have explored dapoxetine for depression or anxiety, its short half-life makes it unsuitable for continuous antidepressant therapy.

Recommended Dapoxetine Dosage by Age and Condition

Typical Duration

• Onset of action: 30–60 minutes
• Peak effect: 1–2 hours
• Total duration: About 4–6 hours after dosing

Practical Tips to Maximize Effectiveness

• Take at the right time — about 1 to 3 hours before sex for best performance.
• Avoid alcohol and recreational drugs, which interfere with serotonin pathways and increase dizziness risk.
• Eat light – high-fat meals can slightly delay absorption and onset.
• Stay consistent – use it several times before judging its full effect. Many men experience better control after the first 3–6 uses.
• Manage anxiety – psychological stress can trigger premature ejaculation; relaxation techniques can improve results.
• Discuss combination therapy – some men benefit from using dapoxetine with sildenafil (Viagra) under doctor supervision, especially if both PE and ED are present.

Clinical Insight

Studies show that combining dapoxetine with behavioral techniques (like the “stop-start” method) produces longer-lasting improvement than medication alone. Remember: do not self-adjust dosage – higher doses don’t always mean better results.

Comparison: Dapoxetine vs Sildenafil and Other PE Treatments (2025 Overview)

Common Dapoxetine Side Effects

• Nausea (up to 10–20%)
• Dizziness or lightheadedness
• Headache
• Insomnia
• Diarrhea
• Dry mouth

These effects often diminish after several doses as your body adjusts.

Serious Side Effects (Rare)

• Fainting or syncope, especially when combined with alcohol or in dehydration
• Mood changes (irritability, anxiety, or mild depressive symptoms)
• Blurred vision or confusion (uncommon)
• Serotonin syndrome, if combined with other serotonergic agents or MAO inhibitors

If you experience fainting, palpitations, or severe mood changes, stop using the drug and seek medical advice immediately.

Contraindications

• History of cardiac arrhythmia or fainting spells
• Severe liver disease
• Concurrent use of SSRIs, SNRIs, MAOIs, or lithium
• Uncontrolled psychiatric disorders

Safety Warnings

• Do not combine dapoxetine with alcohol — it significantly increases the risk of fainting.
• Avoid taking with other serotonin-affecting drugs to reduce the risk of serotonin toxicity.
• Always follow your doctor’s instructions for dosage and timing.

Current Market Overview

• Europe (U.K., Germany, France): Prescription-only under the brand Priligy, priced between €3–€6 per 60mg tablet.
• Canada: Generic dapoxetine available via online pharmacies with doctor authorization.
• Australia: Available as Priligy 30mg / 60mg, prescription required.
• United States: Not FDA-approved; imports restricted to personal use under strict regulation.

Where to Buy Dapoxetine

If you search for dapoxetine where to buy or buy dapoxetine online, make sure the source is a licensed international pharmacy. Reputable options include:

• Online pharmacies registered with the MHRA (U.K.) or EMA (EU).
• Services that provide a digital prescription after a teleconsultation.
• Avoid “no-prescription” websites — these are illegal and often sell counterfeit pills.

Price Summary (2025 Estimates)

• Priligy 30mg: $4–$8 per tablet (international market)
• Priligy 60mg: $6–$12 per tablet
• Generic dapoxetine: $3–$6 per tablet

Although you can buy dapoxetine online, it’s essential to ensure that the seller provides legitimate pharmacy verification and doctor authorization.

How to Buy Dapoxetine Safely

1. Prescription required: Only buy from pharmacies that request a prescription or provide a legitimate telehealth consultation.
2. Check credentials: In the U.K. or EU, look for registration with MHRA (Medicines and Healthcare products Regulatory Agency) or EMA.
3. Avoid “no-prescription” sites: These are illegal and often sell counterfeit drugs.
4. Compare prices carefully: Genuine Priligy dapoxetine usually costs between $6–$12 per 60mg tablet.
5. Consider generic options: Reputable generics are available through international pharmacies in Canada, the U.K., and Australia.

Important Note

If you live in the United States, you can only obtain dapoxetine via import for personal use (in limited quantities, typically under 3-month supply) and only from verified sources. U.S.-licensed physicians may prescribe alternative SSRIs or recommend behavioral therapy when dapoxetine is unavailable.

Official Recommendations

• Take 1 tablet (30–60 mg) only when needed, 1–3 hours before sexual activity.
• Do not take more than one dose in 24 hours.
• Daily or continuous dosing is not approved and should only be done under specialist supervision for experimental or research purposes.

Some men may combine behavioral therapy with dapoxetine as needed, achieving long-term control over premature ejaculation without daily medication.

Brand vs Generic: Key Differences

Both brand-name and generic dapoxetine deliver identical clinical benefits when sourced from certified manufacturers. Always confirm that your generic medication comes from a reputable and licensed supplier.

Elderly Men

Clinical data on dapoxetine in men over 65 are limited. Use is not recommended in this population due to altered metabolism and increased fainting risk.

Cardiovascular Conditions

Men with heart rhythm disorders, uncontrolled hypertension, or fainting history should avoid dapoxetine. Always discuss your cardiac history with your doctor before starting treatment.

Liver and Kidney Impairment

• Mild to moderate liver impairment: Start at 30 mg with caution.
• Severe hepatic or renal impairment: Contraindicated – the drug may accumulate to unsafe levels.

Diabetic Patients

Dapoxetine can be used in diabetic men, provided glucose levels and other medications are stable.

Mental Health Considerations

Men with depression or bipolar disorder should not use dapoxetine concurrently with antidepressants or mood stabilizers, as this increases serotonin syndrome risk.

Interactions to Avoid

• SSRIs (fluoxetine, paroxetine, sertraline)
• MAO inhibitors
• Thioridazine
• Tramadol or linezolid
• Recreational drugs (MDMA, LSD)