Manufacturer: Various
Known as: Aciclovir Cream / Acyclovir Ointment
| Package | Price | Per tube |
|---|---|---|
| 1 tube | $22.86 | $22.86 |
| Package | Price | Per tube |
|---|---|---|
| 1 tube | $18.18 | $18.18 |
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Description of Aciclovir Cream
Aciclovir Cream 5% is a topical antiviral medication widely prescribed for the treatment of herpes simplex virus infections, primarily recurrent cold sores (herpes labialis). It is also sometimes used as part of therapy for genital herpes outbreaks. Unlike oral antivirals, this cream is applied directly to the affected skin, allowing targeted action at the site of infection.
In the United States and most English-speaking countries, this medicine is not sold as aciclovir cream over the counter. A valid prescription from a licensed healthcare provider is required, because improper use can reduce effectiveness and delay appropriate medical treatment. For this reason, patients should always use the cream under medical supervision and follow dosage instructions provided by their doctor or pharmacist.
Cold sores are caused by the herpes simplex virus type 1 (HSV-1) and occasionally by type 2 (HSV-2). These infections are highly prevalent worldwide, with an estimated 3.7 billion people under the age of 50 infected with HSV-1. Outbreaks can cause discomfort, itching, burning, pain, and social distress. Topical treatments like aciclovir cream 5% help shorten recovery time and reduce symptom severity when applied promptly.
Composition and Active Ingredients
Each gram of aciclovir cream contains 50 mg of acyclovir as the active ingredient. This antiviral substance is a synthetic purine nucleoside analogue that interferes with viral DNA synthesis.
The inactive components include:
- Cetostearyl alcohol – provides consistency and helps spread evenly on the skin.
- Propylene glycol – enhances absorption through the skin layers.
- Mineral oil & white petrolatum – create a protective base that supports healing.
- Poloxamer 407 – stabilizes the emulsion.
- Sodium lauryl sulfate – acts as an emulsifier.
- Purified water – the main solvent.
This balanced formulation ensures stability, efficient penetration, and patient tolerability.
Pharmacological Action
Acyclovir, the active component, is converted by viral thymidine kinase into acyclovir monophosphate inside infected cells. It is then further converted into acyclovir triphosphate, which inhibits viral DNA polymerase. This prevents the herpes virus from replicating, thereby limiting the spread of infection in the affected tissue.
When applied at the earliest signs of an outbreak — tingling, burning, or itching — aciclovir cream for herpes can help reduce healing time by up to half a day to one day compared to placebo. Although this effect may seem modest, patients often report a noticeable improvement in comfort and reduced lesion severity.
It is important to emphasize that the cream is not a cure for herpes. The virus remains dormant in nerve cells and can reactivate, leading to recurrent outbreaks. Therefore, ongoing management, sometimes including oral antivirals, may be required. Patients should discuss aciclovir tablets vs cream with their doctor to determine whether topical or systemic therapy is more appropriate, depending on the frequency and severity of outbreaks.
Indications and Uses
Doctors prescribe aciclovir cream primarily for:
- Recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents (12+).
- Sometimes as supportive treatment in genital herpes outbreaks, though oral antivirals are usually preferred.
- Patients who need localized treatment rather than systemic therapy.
It is most effective when started at the first signs of a cold sore before visible blisters form. Delayed application reduces the clinical benefit.
For Adults
Adults are the main group for which this cream is indicated. Treatment should always be under doctor’s supervision, especially for patients with frequent recurrences, compromised immune systems, or those taking other medications that may interact with antivirals.
The cream is not indicated for children under 12 years unless specifically recommended by a physician.
Buy Aciclovir Cream Online
Price and Current Offers
Many patients search for options to buy aciclovir cream online. Prices may vary depending on brand (Zovirax is the most common brand in the U.S.), quantity, and pharmacy provider. Some online pharmacies offer discounts for bulk purchases or generic alternatives.
It is crucial to purchase from licensed U.S. pharmacies to ensure authenticity and effectiveness. Counterfeit or unregulated sources may contain incorrect dosages or harmful ingredients.
Ordering and Delivery Conditions
In the U.S., aciclovir cream 5% is only available with a prescription. Patients can:
- Request a prescription from their doctor (in-person or via telehealth).
- Upload it to an online pharmacy platform.
- Select delivery options, often including overnight shipping to ensure fast treatment.
Some telemedicine services even include the prescription process as part of the order.
Availability in Pharmacies
While local pharmacies in major U.S. cities often stock aciclovir 5% cream, online availability is usually broader and sometimes more affordable. Online platforms may also provide transparent price comparisons between cream and oral tablets, helping patients understand the difference in cost and therapeutic value.
Dosage and Administration
Treatment with aciclovir cream should always be performed under the guidance of a physician. The cream is for external use only and should not be ingested or applied to mucous membranes such as inside the mouth, eyes, or vagina.
Dosage Table
| Patient Group | Recommended Dosage | Frequency of Use | Duration of Treatment |
|---|---|---|---|
| Adults & adolescents (12+) | Apply a thin layer to affected area | 5 times per day (every ~4 hours while awake) | 4 days |
| Immunocompromised patients | As prescribed by physician; oral therapy may be preferred | Variable | Determined by physician |
Application should start at the first sign of infection (burning, itching, tingling). If symptoms do not improve or worsen, medical review is necessary.
Available Forms
- Cream 5% (topical) – for recurrent herpes labialis.
- Ointment 5% (topical) – less common, but available in some markets.
- Tablets (oral acyclovir) – for systemic treatment of genital herpes, herpes zoster (shingles), or severe recurrent infections.
- Injectable (IV acyclovir) – used in hospitals for serious infections like herpes encephalitis or neonatal herpes.
The choice between aciclovir tablets vs cream depends on the severity of the infection and whether systemic therapy is needed. For most cold sore patients, topical therapy is sufficient, but frequent or severe outbreaks often require oral treatment.
Side Effects and Contraindications
Possible Side Effects
Most patients tolerate aciclovir cream well. However, some may experience:
- Mild skin irritation (redness, dryness, peeling)
- Burning or stinging at the application site
- Itching (pruritus)
Serious side effects are rare, but allergic reactions (rash, swelling, difficulty breathing) require immediate medical attention.
Contraindications
The cream is contraindicated in patients with:
- Known hypersensitivity to acyclovir or valacyclovir
- Severe allergic reactions to any component of the formulation
Patients with compromised immune systems or frequent outbreaks should consult a physician, as oral or intravenous therapy may be more appropriate.
Can You Take Aciclovir with Alcohol?
Interaction with Alcohol
Topical aciclovir cream for herpes has no direct pharmacological interaction with alcohol, since it is applied to the skin and not metabolized systemically in significant amounts.
Consequences of Combining
While moderate alcohol use is not contraindicated, excessive alcohol consumption may weaken the immune system, potentially increasing the frequency and severity of herpes outbreaks. For this reason, patients are advised to limit alcohol intake during treatment to support recovery.
Frequently Asked Questions (FAQ)
Which is better – Aciclovir or its alternatives?
How long does it take for aciclovir cream to work?
Can you take aciclovir cream during pregnancy?
Is it safe for children?
Can it be combined with antibiotics or other drugs?
Sources
- FDA prescribing information for Zovirax® (Acyclovir Cream 5%)
- Mayo Clinic: Acyclovir topical route, usage and safety profile
- MedlinePlus: Acyclovir topical, consumer drug information
- Cleveland Clinic: Acyclovir cream or ointment overview
- Mayo Clinic: Cold sore (herpes labialis) treatment and management options