Manufacturer: Janssen-Cilag (Johnson & Johnson) and other generics (region-dependent)
Known as: Domperidone / Motilium
| Package | Price | Per pill |
|---|---|---|
| 360 pills | $99.99 | $0.28 |
| 270 pills | $81.95 | $0.30 |
| 180 pills | $58.99 | $0.33 |
| 120 pills | $42.99 | $0.36 |
| 90 pills | $34.95 | $0.39 |
| 60 pills | $29.99 | $0.50 |
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Where to Buy Motilium: Accessing Domperidone Safely
Motilium (domperidone) is a dopamine D2-receptor antagonist used in many countries to treat nausea and vomiting and to relieve symptoms of upper gastrointestinal motility disorders. It is usually taken before meals and at bedtime. Availability varies by region: while commonly prescribed outside the U.S., domperidone is not FDA-approved for any indication in the United States.
Understanding Motilium (Domperidone)
Domperidone acts primarily peripherally, enhancing gastric emptying and increasing lower esophageal sphincter tone while reducing nausea. Because it has limited penetration of the blood–brain barrier, it tends to cause fewer central nervous system side effects than some alternatives. However, there are important cardiac safety considerations (see below).
Purchasing Options
- Local Pharmacies: In countries where domperidone is authorized (e.g., EU/UK/Canada), Motilium or generic domperidone can be dispensed with a prescription.
- Online Pharmacies: Use only licensed providers that require a valid prescription and disclose the dispensing pharmacy. Avoid sites offering domperidone without medical screening.
- Mail-Order Services: For chronic use prescribed by a clinician, mail-order fills (90-day supplies) can reduce per-pill cost and ensure continuity.
- International Pharmacies: If purchasing from abroad, verify the pharmacy’s accreditation and the product’s market authorization in that country.
Cost-Effective Buying Tips
- Choose generics: Generic domperidone is usually more affordable than branded Motilium where available.
- Compare prices: Check several licensed pharmacies (retail and online) — prices can vary noticeably.
- Use savings programs: Some pharmacies offer internal discounts or coupons that lower cash prices.
- Larger fills: If clinically appropriate, 60–90 day prescriptions often have a lower per-pill price.
Safety Considerations
Domperidone has been associated with QT-interval prolongation and serious ventricular arrhythmias, particularly at higher doses or in patients with underlying cardiac disease or when combined with other QT-prolonging drugs. Many regulators restrict doses and duration, and recommend avoiding use in patients with known cardiac risk factors.
Common side effects include dry mouth, abdominal cramps, and headache.Hormonal effects (elevated prolactin) can occur, leading to breast symptoms in some patients. Always discuss your medical history and medications with a healthcare provider before use.